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© UCLES 2014 BioMedical Admissions Test 4500/12 Wednesday 5 th November 2014 30 minutes SECTION 2 Scientific Knowledge and Applications Instructions to Candidates Please read this page carefully, but do not open the question paper until you are told that you may do so. A separate answer sheet is provided for this section. Please check you have one. You also require a soft pencil and an eraser. Please complete the answer sheet with your: x BMAT candidate number x centre number x date of birth x name Speed as well as accuracy is important in this section. Work quickly, or you may not finish the paper. There are no penalties for incorrect responses, only points for correct answers, so you should attempt all 27 questions. All questions are worth one mark. Answer on the sheet provided. Most questions ask you to show your choice between options by shading a circle. If questions ask you to write in words or numbers, be sure to write clearly in the spaces provided. If you make a mistake, erase thoroughly and try again. Any rough work should be done on this question paper. Calculators are NOT permitted. Please wait to be told you may begin before turning this page. This paper consists of 20 printed pages and 4 blank pages.  

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3 © UCLES 2014 [Turn over 1The following statements relate to the flow of blood through the heart. 1Oxygenated blood flows through the right side of the heart. 2The vena cava empties deoxygenated blood into the ventricle. 3The heart pumps oxygenated blood through the pulmonary artery. 4There is a valve that prevents backflow of blood from the aorta into the left ventricle. Which of these statements is / are correct? A1 only B2 only C4 only D1 and 3 only E1 and 4 only F1, 2 and 3 only G2, 3 and 4 only 2Which of the following reactions are redox reactions? 1 — 8 E� \ — E� 8 2 Ž E ƒ  \ ƒŽ E 6 3 ‰ E 6 8\ ‰ 8 E 6 4 „:  7; 6 E t \ „ 6 Et 7 A1 and 2 only B1 and 3 only C1 and 4 only D2 and 3 only E2 and 4 only F3 and 4 only

4 © UCLES 2014 3Below are four statements about electromagnetic radiation. 1Microwaves have a shorter wavelength than all other electromagnetic waves. 2For identical amplitudes, waves with the largest wavelength transfer the most energy. 3The speed of electromagnetic waves is inversely proportional to their frequency. 4Ultraviolet radiation can cause cataracts. Which of these statements is / are correct? A1 only B2 only C3 only D4 only E1 and 3 only F1 and 4 only G2 and 3 only H2 and 4 only 4Simplify: ë . ? 8 ë ë . ? 5 : A T v B T T Ev C T T Fv D s v E T Fv T Fsx

5 © UCLES 2014 [Turn over 5Before a cell can divide by mitosis, DNA synthesis has to take place. Following DNA synthesis, the DNA is separated into each half of the cell and then the cell divides. The graph below shows the DNA content per cell over a period of time. Which of the letters on the graph represent the sequence of the three events described above? Cell divides DNA synthesis DNA separates A J K L B J L M C K L M D K M N E L M N F L M J G M N J H M N K

6 © UCLES 2014 6Which row in the table correctly explains why an increase in temperature increases the rate of a reaction? Effect on activation energy of reaction Effect on collision frequency between particlesEffect on proportion of collisions which are successful Adecreases no effect increases Bincreases no effect no effect Cno effect increases no effect Dincreases increases no effect Edecreases no effect no effect Fno effect no effect increases Gdecreases increases increases Hno effect increases increases 7Which one of the following is a unit of current? Aampere / second Bcoulomb × second Cjoule / coulomb Dohm / volt Evolt × ohm Fwatt / volt 8 Given that v ã Hz ä Lt á, express J in terms of L and M. AJ LL EM BJ LtL EuM CJ LtL EvM DJ LL EM Ew EJ LxLM

7 © UCLES 2014 [Turn over 9Insulin is a protein involved in the regulation of human blood glucose levels. Genetic engineering can be used to allow the large-scale production of human insulin. Which statement describes the process of genetic engineering in this case? ATaking insulin from a human and inserting it into the DNA of a bacterium. As the bacterium reproduces, it makes large quantities of insulin DNA that can be used to treat human diabetes. BTaking insulin from a human and inserting it into the DNA of a bacterium. As the bacterium reproduces, it makes large quantities of insulin that can be used to treat human diabetes. CTaking the insulin gene from a human chromosome and inserting it into the DNA of a bacterium. As the bacterium reproduces, it makes large quantities of insulin DNA that can be used to treat human diabetes. DTaking the insulin gene from a human chromosome and inserting it into the DNA of a bacterium. As the bacterium reproduces, it makes large quantities of insulin that can be used to treat human diabetes. ETaking the insulin gene from a human chromosome and replacing it in another human chromosome in the same human, so that it will work better to produce large quantities of insulin. 10Methanol can be oxidised by hydrogen peroxide to produce carbon dioxide and water.   7 E u 6 6\ 6 E 6 What is the value of  when this equation is balanced? A3 B4 C5 D6 E7

8 © UCLES 2014 11Two rods, X and Y, are made from different electrically insulating materials. A student rubs rod X, which is initially uncharged, with a cloth, then holds it near to rod Y. The two rods repel each other. Which statement explains why repulsion occurs in this experiment? ARod X gains electrons from the cloth and rod Y is positively charged. BRod X gains electrons from the cloth and rod Y is uncharged. CRod X gains protons from the cloth and rod Y is negatively charged. DRod X gains protons from the cloth and rod Y is positively charged. ERod X loses electrons to the cloth and rod Y is negatively charged. FRod X loses electrons to the cloth and rod Y is positively charged. GRod X loses protons to the cloth and rod Y is negatively charged. HRod X loses protons to the cloth and rod Y is uncharged.

9 © UCLES 2014 [Turn over 12 In a town, the bearing of the library from the station is T Ü. The theatre is due east of the library. The theatre and the station are equidistant from the library. What is the bearing (in degrees) of the station from the theatre? Avw E @T t A B{r F @T t A C{r E @T t A Dszr E T Ettw F @T t A Fttw E @T t A Gtyr  @T t A

10 © UCLES 2014 13In humans, the water content in the blood is regulated via the hormonal system. Which of the following occur when the water content of the blood is too low? 1pituitary gland releases less ADH 2pituitary gland releases more ADH 3increase in water reabsorption by the kidneys 4decrease in water reabsorption by the kidneys 5increased reabsorption of glucose in the kidneys 6decreased reabsorption of glucose in the kidneys A1 and 3 only B2 and 3 only C1 and 4 only D2 and 4 only E1, 3 and 5 only F2, 4 and 6 only G1, 4 and 5 only H2, 3 and 6 only

11 © UCLES 2014 [Turn over 14Which of the following statements about but-1-ene are true? 1it can form a polymer 2 it contains  single bonds only 3 it conforms to the general formula  l 6 l 4it decolourises bromine water 5it is saturated A1, 2 and 3 only B1, 2 and 5 only C1, 3 and 4 only D1, 3 and 5 only E2, 3 and 5 only F2, 3 and 4 only G2, 4 and 5 only H3, 4 and 5 only

12 © UCLES 2014 15A container is filled with water at 20 °C and placed in a room that is also at 20 °C. The container can be fitted with an internal electric cooling unit, in one of the three labelled positions P, Q or R. The outside of the container can either be painted dull black, or be covered in shiny aluminium foil. In order to cool all the water as quickly as possible to 5 °C, in which position should the cooling unit be fitted, and should the outside of the container be dull black or shiny? Position of cooling unit Outside of container AP black BP shiny CQ black DQ shiny ER black FR shiny

13 © UCLES 2014 [Turn over 16Three classes in a school all took the same test. Class 1 achieved a mean score of 61, Class 2 achieved a mean score of 63, and class 3 achieved a mean score of 70. The mean score of the students for all three classes combined was 65. Class 1 contains twice as many students as Class 2. Which one of the following statements about the number of students in class 3 is true? AClass 3 contains fewer students than Class 2. BClass 3 contains the same number of students as Class 2. CClass 3 contains more students than Class 2, but fewer than Class 1. DClass 3 contains the same number of students as Class 1. EClass 3 contains more students than Class 1. 17Which of the following statements about lipid digestion in the small intestine is / are correct? 1Emulsification by bile makes smaller lipid droplets, each with a smaller surface area. 2Bile contains an alkali to reduce the pH of the material from the stomach. 3Lipase secreted in bile breaks bonds in lipids to produce glycerol and fatty acids. Anone of the statements B1 only C2 only D3 only E1 and 2 only F2 and 3 only G1 and 3 only H1, 2 and 3

14 © UCLES 2014 18An organic compound is found to contain 6 parts of carbon, 1 part of hydrogen and 8 parts of oxygen by mass. 6 g of a gaseous sample of the compound would have a volume of 2.4 dm 3 at room temperature and pressure. Which formula (A–E) is the molecular formula for this compound? (A r: H = 1; C = 12; O = 16) (1 mole of any gas occupies 24 dm 3at room temperature and pressure) A 6 B 6 8 6 C 7

15 © UCLES 2014 [Turn over 20The diagram shows part of a glass structure. PQRS is a horizontal square with sides of 1 metre, and point X is 4 metres vertically above P. What is the cosine of the angle that XR makes with the horizontal? As u B¾t v C¾t t ¾u Dv u ¾t Et ¾u Fs ¾sy Gs sy

16 © UCLES 2014 21In order to function, the cells of the brain need large amounts of energy. Any reduction in the function of these cells can have serious consequences for the body. For example, a loss of oxygen supply to the brain can cause unconsciousness within 5–10 seconds. Which of the following statements are true? 1Neurons in the brain are capable of relying on anaerobic respiration for long periods of time. 2The homeostatic systems of the body will constantly have to work to resist temperature increases in the brain. 3An overdose of insulin in the body could produce a serious loss of brain function, such as inducing a coma. 4During normal functioning of neurons in the brain, high levels of carbon dioxide could be produced. A1 and 2 only B1 and 3 only C2 and 3 only D2 and 4 only E1, 3 and 4 only F1, 2 and 4 only G2, 3 and 4 only

17 © UCLES 2014 [Turn over 22Graphene is a new material composed of carbon atoms arranged in tightly bound hexagons just one atom thick. The diagram shows a simplified structure of graphene. Considering its structure, which of the properties below could be predicted about graphene? 1high melting point 2good electrical conductivity 3soluble in water A1 only B2 only C3 only D1 and 2 only E1 and 3 only F2 and 3 only G1, 2 and 3

18 © UCLES 2014 23When a particular nucleus of uranium-235 undergoes the process of nuclear fission, it absorbs a neutron and then splits into a nucleus of barium and a nucleus of krypton, as well as releasing further neutrons. Which one of the rows of the table below gives the correct number of neutrons released and the isotopes of barium and krypton produced by this nuclear reaction? Number of neutrons released Mass number of barium isotope produced Mass number of krypton isotope produced A2 141 92 B2 142 94 C3 140 92 D3 140 94 E3 141 92 F3 142 94

19 © UCLES 2014 [Turn over 24A test is developed to detect a certain medical condition. The test is not perfect, and sometimes gives incorrect results. The behaviour of the test on 1000 randomly selected members of the population is shown in this tree diagram, where the following notation is used: x% L has the condition x% ñ L does not have the condition x6 L tests positive for the condition x6" L tests negative for the condition Three of the branches’ proportions are shown in the tree diagram: x 5 5 4 4 of the 1000 people have the condition x 8 9 of those with the condition test positive for the condition x 5 5 4 of those without the condition test positive for the condition A person is selected at random from these 1000 people, and tests positive for the condition. What is the probability that this person has the condition? Av w B{ sr C{ tr Dz {{ Ez sry Fv wrr Gsry srrr

20 © UCLES 2014 25A woman has a recessive genetic condition but neither of her parents has the condition. Which one of the following could not be true? ABoth her parents are heterozygous for this gene. BOne maternal grandparent and one paternal grandparent have the condition. COne maternal grandparent and one paternal grandparent are heterozygous for this gene. DAll her grandparents were carriers of the recessive allele. EBoth parents are homozygous and a mutation occurred in the DNA of a gamete from one of her parents. 26Which of the following atoms / ions contain(s) exactly 18 electrons? 1  z sz 2  sx uv 3 Ž sy uw 4 Ž  sy uy 5 ƒ 6 > tr vr  A1 only B2 only C2 and 3 only D3 and 4 only E4 and 5 only

21 © UCLES 2014 27The graph shows the variation with time of the height through which a crane lifts a mass of 20 kg. Assume the gravitational field strength g is 10 N / kg, and that the effects of air resistance and friction are negligible. What is the power output of the crane when the mass is at a height of 10 m? A0.1 W B10 W C40 W D100 W E400 W F4000 W

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